Cytotoxic fatty acid amides from Xenorhabdus.
نویسندگان
چکیده
منابع مشابه
Microsomal synthesis of fatty acid amides.
A microsomal system is described which catalyzes the formation of fatty acid amides of ethanolamine and of several pharmacologically active amines. Although the system has no dependance on external energy sources and has a high K, for the amine substrate, it has several characteristics which differ markedly from an amide hydrolytic system in the microsomes. A possible mechanism for the formatio...
متن کاملThe entomopathogenic bacterium, Xenorhabdus nematophila, impairs hemocytic immunity by inhibition of eicosanoid biosynthesis in adult crickets, Gryllus Wrmus
The bacterium, Xenorhabdus nematophila (Poinar and Thomas), is an obligate symbiont of nematodes in the genus Steinernema and a lethal insect pathogen. We investigated the hypothesis that one aspect of the bacterial virulence is the ability of X. nematophila to severely impair host insect cellular immune reactions to infection by inhibiting eicosanoid biosynthesis in the adult male cricket, Gry...
متن کاملAnandamide, Oleamide and Other Simple Fatty Amides
Fatty amides are produced synthetically in industry in large amounts (> 300,000 tons per annum) for use as ingredients of detergents, lubricants, inks and many other products. In nature, fatty acids are linked to the complex sphingolipids via amide bonds. However, here we are concerned only with those simple fatty amides that occur naturally, some of which have profound biological functions. Si...
متن کاملA Computational Study of Cytotoxicity of Substituted Amides of Pyrazine-2-carboxylic acids Using QSAR and DFT Based Molecular Surface Electrostatic Potential
Pyrazine derivatives are important class of compounds with diverse biological and cytotoxic activities and clinical applications. In this study, B3 p 86 / 6 – 31 + + G * was used to compute and map the molecular surface electrostatic potentials of a group of substituted amides of pyrazine-2-carboxylic acids to identify common features related to their subsequent cytotoxicities. Several statisti...
متن کاملFatty acid amide hydrolase substrate specificity.
Fatty acid amide hydrolase (FAAH), also referred to as oleamide hydrolase and anandamide amidohydrolase, is a serine hydrolase responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers. FAAH hydrolyzes a range of fatty acid amides, and the present study examines the relative rates of hydrolysis of a variety of natural and unnat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chembiochem : a European journal of chemical biology
دوره 12 13 شماره
صفحات -
تاریخ انتشار 2011